SPRAVATO® Effectively Treats Depression!

Now Available at Chester Neurology – REMS-Certified Treatment Center

What is SPRAVATO®?

SPRAVATO® (esketamine) nasal spray is an FDA-approved prescription medicine used in combination with an oral antidepressant to treat:

  • Treatment-Resistant Depression (TRD) in adults
  • Depressive symptoms in adults with Major Depressive Disorder (MDD) who have suicidal thoughts or actions

SPRAVATO® offers a breakthrough approach to treatment by targeting the brain’s
glutamate system—acting differently than traditional antidepressants and, in many cases,  providing rapid symptom relief.

Why SPRAVATO® for Depression?

SPRAVATO® (esketamine) nasal spray offers a groundbreaking approach for adults
living with Treatment-Resistant Depression (TRD) or Major Depressive Disorder
(MDD) with suicidal thoughts or actions. Unlike traditional antidepressants that act on
serotonin or norepinephrine, SPRAVATO® works on the brain’s glutamate system,
helping restore connections in brain regions affected by depression.

Take the first step

to overcoming your depression today

Find out whether SPRAVATO® treatment is right for you!

Get Started

Why Choose SPRAVATO® at Chester Neurology?

At Chester Neurology, we understand how difficult the journey with depression can be.
As a REMS-certified treatment center, we are fully equipped to safely administer
SPRAVATO® under medical supervision.

Our compassionate team is here to guide you every step of the way—from your initial consultation and insurance coordination to treatment sessions and ongoing care.

How SPRAVATO® Works

Unlike oral antidepressants that may take weeks to show effect, SPRAVATO® works on NMDA receptors in the brain. Many patients experience rapid symptom improvement—some within the first few treatments.

It is self-administered as a nasal spray in our office under direct medical supervision.

SPRAVATO® at a Glance: Why Patients Choose It

Works Fast

In clinical studies, patients began feeling better than those receiving a placebo within 24 hours of their first dose.

Results Improve Over Time

Ongoing treatment with SPRAVATO® continued to reduce depression symptoms beyond the first dose—patients felt better and better.

Keeps on Working

Long-term data shows that SPRAVATO®’s effects do not fade over time. Patients not only improve but maintain their progress over months and years of treatment.

What to Expect

Before Treatment
  • After a psychiatric evaluation, if you and your provider determine SPRAVATO® is right for you, you’ll complete a Patient Intake Form.

  • Our team will confirm insurance coverage and go over any costs before starting treatment.
During Treatment
  • Each SPRAVATO® session takes place in a private, comfortable setting in our office.

  • You will self-administer the nasal spray under medical supervision.

  • Our healthcare providers will monitor you for at least 2 hours for side effects like sedation, dizziness, or dissociation.

  • Vital signs including blood pressure and oxygen levels are closely tracked.
After Treatment
  • You cannot drive after treatment—please arrange for a ride home.

  • Most patients can resume regular activities the following day after a restful night’s sleep.

Frequently Asked Questions

Yes, SPRAVATO® is FDA-approved and only available through certified treatment
centers like Chester Neurology.

Treatment usually starts twice weekly for the first four weeks, then tapers to weekly or
biweekly.

Our team works with your insurance provider to confirm coverage before treatment
begins.

No. You must arrange for someone to drive you home after treatment.

You’ll stay at the office for at least two hours after treatment for safety monitoring.

What Patients Are Saying

“After years of trying every antidepressant out there, I finally feel like myself again. SPRAVATO® helped me in a way nothing else ever has.”

“The experience in the clinic is calming and supportive. I feel safe every time I come in for my treatment.” — SPRAVATO® Patient Testimonial

SPRAVATO® Dosing Schedule

SPRAVATO® (esketamine) nasal spray is administered in conjunction with an oral
antidepressant. The dosing schedule is divided into two phases: the Induction Phase and the Maintenance Phase.

Induction Phase (Weeks 1 to 4)
  • Frequency: Twice per week​
  • Dosage:
  • Starting Dose (Day 1): 56 mg​
  • Subsequent Doses: 56 mg or 84 mg, as determined by your healthcare provider based on efficacy and tolerability.
Maintenance Phase (Week 5 and Beyond)
  • Weeks 5 to 8:
    o Frequency: Once weekly​
    o Dosage: 56 mg or 84 mg, as determined by your healthcare provider.​         

  • Week 9 and After:
  • Frequency: Every 2 weeks or once weekly, individualized to the least frequent dosing to maintain remission/response.​
  • Dosage: 56 mg or 84 mg, as determined by your healthcare provider

Getting Started with SPRAVATO®

You’ve decided to try SPRAVATO® — what’s next?

Once you and your healthcare provider have decided SPRAVATO® is right for you — and you understand the benefits and risks — you can begin planning your treatment at a
certified center like Chester Neurology.

1. Your SPRAVATO® Treatment Plan

– SPRAVATO® is taken alongside an oral antidepressant.

– It is typically administered twice a week for the first 4 weeks. After that, the frequency is adjusted based on how you’re responding.

– All treatments are supervised at a certified treatment center like ours, as part of the SPRAVATO® REMS (Risk Evaluation and Mitigation Strategy) Program.

Note: Our team will help you locate the right treatment schedule and walk you through the process from your first dose through maintenance treatment.

2. Your First Visit to Chester Neurology

During your initial consultation at our REMS-certified center, we will:

– Review your medical records and history from your referring provider.

– Perform our own assessment to determine if SPRAVATO® is the right treatment for you.

– Confirm your insurance coverage and eligibility.

– If approved, enroll you in the SPRAVATO® REMS Program and build a personalized treatment plan.

Ask the Experts

Still have questions about SPRAVATO®?

Hear directly from leading mental health experts, healthcare professionals, and patients who’ve experienced SPRAVATO® treatment firsthand.
Explore expert videos that explain how SPRAVATO® works, what to expect, and why it may be a life-changing treatment option:

What is SPRAVATO® and how does it work?
Hear from real patients and caregivers
Learn about the REMS program and treatment journey

Important Safety Information

Potential side effects include:

Sleepiness, dizziness, nausea
Dissociation
Increased blood pressure
Risk of abuse and misuse
Respiratory issues

SPRAVATO® is only available through a restricted program called the REMS Program.
Chester Neurology is proud to be REMS-certified.

Is SPRAVATO® Right for You?

SPRAVATO® may be an option if:

– You’ve tried two or more antidepressants without adequate relief
– You’re struggling with suicidal thoughts alongside depression

Talk to your psychiatrist or schedule a consultation at Chester Neurology to explore if this innovative treatment is right for you.

Contact Us

To learn more or begin the intake process, call us at 914-816-1941 or use our contact form. We’re here to support you in your journey toward relief and recovery.

Scroll to Top